When you’re being treated for alcohol use disorder, it’s possible that your provider will include Antabuse in your care plan. 

Also known by its generic name of disulfiram, Antabuse is a medication designed to support people who want to stop drinking by creating a strong physical reaction when alcohol is consumed. Antabuse is most effective when it’s taken consistently and as part of a broader treatment plan that may include medication management, medical monitoring and supportive care.

Like all medications, Antabuse can cause side effects. But knowledge is power. Knowing what physical and emotional impact is normal, and how to stay safe, can help you feel more prepared during treatment.

Read on to learn common Antabuse side effects, safety considerations and when it’s important to check in with your provider.

5 common Antabuse side effects

Antabuse works as a deterrent by interfering with how the body processes alcohol. But some side effects can occur even if you avoid alcohol completely. Here are five of the most common Antabuse side effects to be aware of:

• Fatigue or drowsiness 

It’s common to feel more tired than usual when starting Antabuse. Some people notice low energy or mild drowsiness during the day. 

This side effect often improves over time, but it can help to take the medication at the same time each day. You should also avoid driving or operating heavy machinery until you know how Antabuse affects you.

Let your provider know if fatigue interferes with your daily responsibilities.

• Headaches

Headaches are another frequently reported Antabuse side effect, especially when you’re just starting treatment. The headaches are usually temporary and tend to be mild to moderate in severity.

If you’re trying to reduce the frequency and severity of headaches as your body gets used to the medication, staying hydrated is essential. You should also prioritize getting enough rest and maintaining a consistent sleep schedule. 

If your headaches are persistent or severe, check in with your provider.

• Metallic or garlic-like taste

It’s possible for Antabuse to leave a lingering taste after you’ve taken it. Some people experience a lingering metallic or garlic-like taste in their mouth while taking it. It stems from your body releasing carbon disulfide as it breaks down the medication.

Even though it’s harmless, knowing about this possible side effect can prevent you from being confused by the odd taste or overanalyzing what you’ve recently eaten. The taste can be managed with good oral hygiene, lozenges and staying hydrated.

• Skin reactions

Mild skin reactions, such as rashes or itching, can occur while taking Antabuse. These are usually not dangerous, but they shouldn’t be ignored, especially if they cause physical discomfort.

Contact your provider if you notice:

• A widespread rash
• Hives
• Swelling or redness that worsens over time

• Mild gastrointestinal discomfort

Antabuse may cause nausea, upset stomach or changes in appetite, even without alcohol exposure.

If you’re trying to manage this uncomfortable side effect, you can try eating balanced meals and avoiding spicy or greasy foods. Be sure to take the medication exactly as prescribed to reduce your side effects as much as possible, including gastrointestinal difficulties. 

Safety considerations while taking Antabuse

Safety is the priority in every treatment plan for people experiencing alcohol use disorder, and that goes beyond just avoiding alcohol. When taking Antabuse, ongoing communication with your provider plays a key role in successful and safe treatment.

Safety considerations about Antabuse to keep in mind include:

• Taking the medication exactly as prescribed
• Attending regular medication management appointments
• Sharing all medications, supplements and medical conditions with your provider
• Avoiding alcohol for at least two weeks after stopping Antabuse to reduce the risk of reactions

Antabuse may not be appropriate for everyone, especially people with certain medical conditions, such as cardiovascular or liver disease. Your provider will help determine whether it’s a good fit for your needs and goals.

What happens if you drink alcohol while taking Antabuse?

Antabuse helps deter you away from alcohol by causing an extremely unpleasant physical reaction when it’s consumed. 

Drinking alcohol while on Antabuse can trigger:

• Flushing of the face and chest
• Throbbing headache
• Nausea and vomiting
• Rapid heartbeat
• Shortness of breath
• Dizziness or confusion

These reactions can begin within minutes and may last for several hours. In severe cases, they can be dangerous and require medical attention.

One of the most important safety considerations with Antabuse is avoiding all forms of alcohol, which goes beyond just alcoholic beverages. Alcohol can also be found in unexpected products, including:

• Mouthwash
• Certain cough syrups
• Cooking sauces
• Some skincare or hygiene products

Be sure to carefully read labels. You can also ask your provider or pharmacist about potential sources of alcohol to reduce the risk of accidental consumption.

ReKlame can help you stay safe while taking Antabuse

Safety considerations should be taken every step of the way through your treatment program. If you’ve been prescribed Antabuse for your alcohol use disorder, it’s essential that you monitor your side effects, take the right steps to stay safe and have transparent communication with your providers.

At ReKlame, our virtual medication management services can help you stay on top of your side effects to determine when possible changes need to be made to your prescription for the best long-term progress on your recovery journey.

Give our care team a call today for more information, check your eligibility for free online or book an initial appointment online.